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Thermo Fisher gene exp c1qc hs00757779 m1
Complement deposition at NMJ and gene expression of complement factors. a Enzyme histochemical preparation by non-specific esterase shows motor endpoint regions with terminal nerve bundles (asterisk) and neuromuscular junctions (NMJ, white arrows) in LRP4-ab + and AChR-ab+-MG patients as well as non-diseased controls (NDC). Only in myasthenia gravis (MG) patients, NMJ are stained positive for C5b-9. Note, physiological positivity of small arterioles (with a lumen) in NDC muscle tissues, while endplates are not stained. b Counting of C5b-9 positive endplates in the whole slide demonstrated a range of 6–96% and a mean of 46% C5b-9 + endplates in LRP4-ab + MG patients (double positive patients marked in orange), while in AChR+ patients, range was 33–100% with a mean of 75%. c Gene transcript analyses of complement factors via qPCR demonstrated increased expression of <t>C1QC</t> and C3 in MG patients without reaching statistical significance. Statistics with Ordinary one-way ANOVA with Tukey´s multiple comparison test or Mann-Whitney U test, p < 0.05. LRP4/AChR-double positive patients marked in orange
Gene Exp C1qc Hs00757779 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 89/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Bioss antic1qc c1qg hrp polyclonal antibody
Complement deposition at NMJ and gene expression of complement factors. a Enzyme histochemical preparation by non-specific esterase shows motor endpoint regions with terminal nerve bundles (asterisk) and neuromuscular junctions (NMJ, white arrows) in LRP4-ab + and AChR-ab+-MG patients as well as non-diseased controls (NDC). Only in myasthenia gravis (MG) patients, NMJ are stained positive for C5b-9. Note, physiological positivity of small arterioles (with a lumen) in NDC muscle tissues, while endplates are not stained. b Counting of C5b-9 positive endplates in the whole slide demonstrated a range of 6–96% and a mean of 46% C5b-9 + endplates in LRP4-ab + MG patients (double positive patients marked in orange), while in AChR+ patients, range was 33–100% with a mean of 75%. c Gene transcript analyses of complement factors via qPCR demonstrated increased expression of <t>C1QC</t> and C3 in MG patients without reaching statistical significance. Statistics with Ordinary one-way ANOVA with Tukey´s multiple comparison test or Mann-Whitney U test, p < 0.05. LRP4/AChR-double positive patients marked in orange
Antic1qc C1qg Hrp Polyclonal Antibody, supplied by Bioss, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Proteintech c1qc
Complement deposition at NMJ and gene expression of complement factors. a Enzyme histochemical preparation by non-specific esterase shows motor endpoint regions with terminal nerve bundles (asterisk) and neuromuscular junctions (NMJ, white arrows) in LRP4-ab + and AChR-ab+-MG patients as well as non-diseased controls (NDC). Only in myasthenia gravis (MG) patients, NMJ are stained positive for C5b-9. Note, physiological positivity of small arterioles (with a lumen) in NDC muscle tissues, while endplates are not stained. b Counting of C5b-9 positive endplates in the whole slide demonstrated a range of 6–96% and a mean of 46% C5b-9 + endplates in LRP4-ab + MG patients (double positive patients marked in orange), while in AChR+ patients, range was 33–100% with a mean of 75%. c Gene transcript analyses of complement factors via qPCR demonstrated increased expression of <t>C1QC</t> and C3 in MG patients without reaching statistical significance. Statistics with Ordinary one-way ANOVA with Tukey´s multiple comparison test or Mann-Whitney U test, p < 0.05. LRP4/AChR-double positive patients marked in orange
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Bioss anti c1qc c1qg hrp polyclonal antibody
Complement deposition at NMJ and gene expression of complement factors. a Enzyme histochemical preparation by non-specific esterase shows motor endpoint regions with terminal nerve bundles (asterisk) and neuromuscular junctions (NMJ, white arrows) in LRP4-ab + and AChR-ab+-MG patients as well as non-diseased controls (NDC). Only in myasthenia gravis (MG) patients, NMJ are stained positive for C5b-9. Note, physiological positivity of small arterioles (with a lumen) in NDC muscle tissues, while endplates are not stained. b Counting of C5b-9 positive endplates in the whole slide demonstrated a range of 6–96% and a mean of 46% C5b-9 + endplates in LRP4-ab + MG patients (double positive patients marked in orange), while in AChR+ patients, range was 33–100% with a mean of 75%. c Gene transcript analyses of complement factors via qPCR demonstrated increased expression of <t>C1QC</t> and C3 in MG patients without reaching statistical significance. Statistics with Ordinary one-way ANOVA with Tukey´s multiple comparison test or Mann-Whitney U test, p < 0.05. LRP4/AChR-double positive patients marked in orange
Anti C1qc C1qg Hrp Polyclonal Antibody, supplied by Bioss, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Galectin Therapeutics c1qc
Complement deposition at NMJ and gene expression of complement factors. a Enzyme histochemical preparation by non-specific esterase shows motor endpoint regions with terminal nerve bundles (asterisk) and neuromuscular junctions (NMJ, white arrows) in LRP4-ab + and AChR-ab+-MG patients as well as non-diseased controls (NDC). Only in myasthenia gravis (MG) patients, NMJ are stained positive for C5b-9. Note, physiological positivity of small arterioles (with a lumen) in NDC muscle tissues, while endplates are not stained. b Counting of C5b-9 positive endplates in the whole slide demonstrated a range of 6–96% and a mean of 46% C5b-9 + endplates in LRP4-ab + MG patients (double positive patients marked in orange), while in AChR+ patients, range was 33–100% with a mean of 75%. c Gene transcript analyses of complement factors via qPCR demonstrated increased expression of <t>C1QC</t> and C3 in MG patients without reaching statistical significance. Statistics with Ordinary one-way ANOVA with Tukey´s multiple comparison test or Mann-Whitney U test, p < 0.05. LRP4/AChR-double positive patients marked in orange
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Proteintech anti c1qc
Complement deposition at NMJ and gene expression of complement factors. a Enzyme histochemical preparation by non-specific esterase shows motor endpoint regions with terminal nerve bundles (asterisk) and neuromuscular junctions (NMJ, white arrows) in LRP4-ab + and AChR-ab+-MG patients as well as non-diseased controls (NDC). Only in myasthenia gravis (MG) patients, NMJ are stained positive for C5b-9. Note, physiological positivity of small arterioles (with a lumen) in NDC muscle tissues, while endplates are not stained. b Counting of C5b-9 positive endplates in the whole slide demonstrated a range of 6–96% and a mean of 46% C5b-9 + endplates in LRP4-ab + MG patients (double positive patients marked in orange), while in AChR+ patients, range was 33–100% with a mean of 75%. c Gene transcript analyses of complement factors via qPCR demonstrated increased expression of <t>C1QC</t> and C3 in MG patients without reaching statistical significance. Statistics with Ordinary one-way ANOVA with Tukey´s multiple comparison test or Mann-Whitney U test, p < 0.05. LRP4/AChR-double positive patients marked in orange
Anti C1qc, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Proteintech anti c1qa
Complement deposition at NMJ and gene expression of complement factors. a Enzyme histochemical preparation by non-specific esterase shows motor endpoint regions with terminal nerve bundles (asterisk) and neuromuscular junctions (NMJ, white arrows) in LRP4-ab + and AChR-ab+-MG patients as well as non-diseased controls (NDC). Only in myasthenia gravis (MG) patients, NMJ are stained positive for C5b-9. Note, physiological positivity of small arterioles (with a lumen) in NDC muscle tissues, while endplates are not stained. b Counting of C5b-9 positive endplates in the whole slide demonstrated a range of 6–96% and a mean of 46% C5b-9 + endplates in LRP4-ab + MG patients (double positive patients marked in orange), while in AChR+ patients, range was 33–100% with a mean of 75%. c Gene transcript analyses of complement factors via qPCR demonstrated increased expression of <t>C1QC</t> and C3 in MG patients without reaching statistical significance. Statistics with Ordinary one-way ANOVA with Tukey´s multiple comparison test or Mann-Whitney U test, p < 0.05. LRP4/AChR-double positive patients marked in orange
Anti C1qa, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Complement deposition at NMJ and gene expression of complement factors. a Enzyme histochemical preparation by non-specific esterase shows motor endpoint regions with terminal nerve bundles (asterisk) and neuromuscular junctions (NMJ, white arrows) in LRP4-ab + and AChR-ab+-MG patients as well as non-diseased controls (NDC). Only in myasthenia gravis (MG) patients, NMJ are stained positive for C5b-9. Note, physiological positivity of small arterioles (with a lumen) in NDC muscle tissues, while endplates are not stained. b Counting of C5b-9 positive endplates in the whole slide demonstrated a range of 6–96% and a mean of 46% C5b-9 + endplates in LRP4-ab + MG patients (double positive patients marked in orange), while in AChR+ patients, range was 33–100% with a mean of 75%. c Gene transcript analyses of complement factors via qPCR demonstrated increased expression of C1QC and C3 in MG patients without reaching statistical significance. Statistics with Ordinary one-way ANOVA with Tukey´s multiple comparison test or Mann-Whitney U test, p < 0.05. LRP4/AChR-double positive patients marked in orange

Journal: Acta Neuropathologica Communications

Article Title: Complement deposition, IgG subtyping and endplate destruction in LRP4-ab-positive myasthenia gravis

doi: 10.1186/s40478-026-02284-0

Figure Lengend Snippet: Complement deposition at NMJ and gene expression of complement factors. a Enzyme histochemical preparation by non-specific esterase shows motor endpoint regions with terminal nerve bundles (asterisk) and neuromuscular junctions (NMJ, white arrows) in LRP4-ab + and AChR-ab+-MG patients as well as non-diseased controls (NDC). Only in myasthenia gravis (MG) patients, NMJ are stained positive for C5b-9. Note, physiological positivity of small arterioles (with a lumen) in NDC muscle tissues, while endplates are not stained. b Counting of C5b-9 positive endplates in the whole slide demonstrated a range of 6–96% and a mean of 46% C5b-9 + endplates in LRP4-ab + MG patients (double positive patients marked in orange), while in AChR+ patients, range was 33–100% with a mean of 75%. c Gene transcript analyses of complement factors via qPCR demonstrated increased expression of C1QC and C3 in MG patients without reaching statistical significance. Statistics with Ordinary one-way ANOVA with Tukey´s multiple comparison test or Mann-Whitney U test, p < 0.05. LRP4/AChR-double positive patients marked in orange

Article Snippet: The qPCR assay identification numbers, TaqMan ® Gene Exp Assay from Life Technologies/ThermoFisher are listed as follows: C1QC Hs00757779_m1, C3 Hs00163811_m1, C5 Hs01004342_m1, PGK1 Hs99999906_m1.

Techniques: Gene Expression, Staining, Expressing, Comparison, MANN-WHITNEY